Recent advancements in magnetic resonance imaging (MRI) have enabled clinical imaging of human cortical bone,\r\nproviding a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to\r\nconventional X-ray-based diagnostics. To this end, 1H nuclear magnetic resonance (NMR) and high-resolution X-ray signals\r\nfrom human cortical bone samples were correlated with mechanical properties of bone. Results showed that 1H NMR\r\nsignals were better predictors of yield stress, peak stress, and pre-yield toughness than were the X-ray derived signals. These\r\n1H NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment\r\nof fracture risk.
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